| External factors: | LG2055 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Immunostaining |
| Description: | We observed that feeding with LG2055 delayed aging, with intestinal lipofuscin( a marker of cellular damage during aging) levels being 12% lower in LG2055-fed worms than in OP50-fed worms. However, the ratio of stained area in the whole body was decreased in LG2055-fed worms compared with that in OP50-fed worms. |
| Target gene: | SKN-1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | POU2F3 |
| Target gene experiment: | GFP localization assay |
| Target gene description: | We observed that extrachromosomal and integrated transgenes driving skn-1c–gfp expression from ges-1 promoter 16 induced stronger fluorescence in LG2055-fed worms than in OP50-fed worms. |
| Regulatory pathway: | p38 MAPK |
| R-EF-Pathway: | Activation |
| Pathway experiment: | Western blot |
| Pathway description: | We observed that feeding with LG2055 altered the expression of genes involved in p38 MAPK signaling ；In addition, levels of phosphorylated p38 were increased in LG2055-fed worms . |
Annotation: