| External factors: | Nicotinamide |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//SAHF |
| Description: | However, in the presence of NAM, the SA-β-gal positive cells’percentage significantly increased in the Y﹢N group compared with that in the young group.The expression of SAHF was significantly increased in Y+N group when compared with that in young cells. |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Western blot//RT-PCR |
| Target gene description: | SIRT1 expression in the Y﹢N group was significantly decreased compared with that in young group.The mRNA expression of SIRT1 in Y﹢N group was significantly decreased compared with that in the young group. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: