| External factors: | H2O2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Telomere length assay//Cell morphological analysis//Cell Cell proliferation assay |
| Description: | SA-β-gal activity assay:Early passage chondrocytes incubated with sub-lethal doses of H2O2 (75–100 mM) showed characteristic features of senescence concerning morphology and positive β-galactosidase staining. Following treatment with sub-lethal doses of H2O2, a significant decrease of proliferation rate was detected in early. Determination of Telomere Length:correlated with cpd in both groups (p < 0.01). With prolonged H2O2 treatment, significant increase in telomere shortening occurred. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: