Aging Overview

External factors

External factors: Autophagy
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Primary biliary cirrhosis
Experimental category: L
Tissue type: --
Cell name: BEC
PMID: 20212459
Experiment: SA-β-gal activity assay
Description: Percentage of cells positive for SA-β-gal was significantl higher in cultured BECs treated with H2O2(SA-β-gal-labeling index, 37.0±13.1), Etoposide (34.0±5.7), and serum deprivation (34.2±11.7), when compared with control without treatment. Percentage of cells positive for SA-β-gal was significantly decreased by a treatment with the autophagy inhibitor 3MA(5 mM) .


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.