| External factors: | CPBMF65 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | HCC |
| Experiment: | NMA analysis//Flow cytometry |
| Description: | We also investigated whether treatment with CPBMF65 would induce senescence, another mechanism that may be involved in decreasing cell proliferation. A significant senescence increase of 9% in HepG2 cells treated with CPBMF65 was observed, while the positive control group (treated with H2O2, 150 μM) presented a 16% senescence increase. In order to explore if the Urd treatment was also capable of inducing senescence, the NMA assay was performed. Results demonstrated that 5 and 10 mM of Urd, as well as 150 μM of H2O2 (positive control), induced an increase of senescence in HepG2 cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: