Aging Overview

External factors

External factors: U0126
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HT-p21
PMID: 19478560
Experiment: Cell morphological analysis
Description: U0126 suppressed senescence.


Regulatory relationship

Regulatory pathway: mTOR-S6
R-EF-Pathway: Downregulation
Official symbol(s): MTOR
Pathway experiment: Western blot
Pathway description: As expected, U0126 inhibited ERK phosphorylation (day 1).Like rapamycin, U0126 inhibited S6 phosphorylation at day 1 .


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view