| External factors: | Centella asiatica |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | H2O2-induced premature senescence decreased by 2.05% after treatment with C. asiatica extracts at 2 ug?ml and by 20.83% at 20 ug?ml. |
| Regulatory pathway: | p53-p21 |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | The results of Western blotting showed that H2O2 induced a robust increase in the expression of p53, p21 and pRb and that pretreatment with C. asiatica extracts inhibited the accumulation of these proteins . |
Annotation: