| External factors: | Tamoxifen |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Breast cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | Similarly, there was a 35% induction of cellular senescence in tamoxifen-treated shLacZ cells that was not observed in either pool of MCF-7 cells expressing shYPEL3. |
| Target gene: | YPEL3 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | YPEL3 |
| Target gene experiment: | RT-PCR |
| Target gene description: | There was a 2.3-fold induction of YPEL3 mRNA expression in control cells (shLacZ) treated with tamoxifen verses vehicle control. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: