Aging Overview

External factors

External factors: CRT0063465
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Hypoglycemia
Experimental category: L
Tissue type: --
Cell name: HCT116
PMID: 31401411
Experiment: Southern blot
Description: Strikingly, however, despite the lack of effects observed on total cellular telomerase activity by CRT0063465, hypoglycemic erosion of telomeres was blocked in the presence of the compound at both 100 nM and 10 nM.


Regulatory relationship

Target gene: PGK1//DJ1
R-EF-Target gene: --//--
Official symbol(s): PGK1//PARK7
Target gene experiment: Co-IP
Target gene description: For PGK1, 10 nM CRT0063465 increased telomere association under physiological glucose conditions.For DJ1, compound treatment did not significantly affect telomere association under physiological conditions.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.