| External factors: | OX-LDL |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cardiovascular disease |
| Experiment: | SA-β-gal activity assay//Western blot//CCK-8 assay |
| Description: | Continuous exposure to 80 μg/ml ox-LDL for 24 h decreased the proliferation of HUVECs, up-regulated the expression of PAI-1 and P21, increased the ratio of cells in G0/G1 phase and positive cells of SA-β-gal staining compared with the control group. |
| Target gene: | P62//SIRT1 |
| R-EF-Target gene: | Upregulation//Downregulation |
| Official symbol(s): | P62//SIRT1 |
| Target gene experiment: | Western blot |
| Target gene description: | Ox-LDL also decreased the ratio of LC3 II/LC3 I, increased the protein level of p62 and decreased the expression of SIRT1 in a dose-dependent manner. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: