External factors: | Radiation |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Other |
Phenotype: | Aging |
Experiment: | SA-β-gal activity assay |
Description: | HUVECs treated with low doses of ionizing radiation showed a significant increase in SA-β-gal+ cells in a dose-dependent manner (p?0.05), suggesting that the low doses of ionizing radiation could cause cell senescence . |
Target gene: | KU86//P16 |
R-EF-Target gene: | Downregulation//Upregulation |
Official symbol(s): | KU86//P16 |
Target gene experiment: | Western blot |
Target gene description: | We also found that the increased ionization caused a significant reduction in Ku86 expression and a significant increase in p16Ink4a expression in a dose-dependent manner. |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: