| External factors: | Doxorubicin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Colorectal cancer |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Doxorubicin induced senescence in a largely p53-dependent manner in HCT116 cells; significantly more senescent cells were observed in HCT116 p53+/+ cells treated with Doxorubicin compared with HCT116 p53?/? cells treated with Doxorubincin . |
| Target gene: | P53 |
| R-EF-Target gene: | -- |
| Official symbol(s): | P53 |
| Target gene experiment: | SA-β-gal activity assay//Knockdown |
| Target gene description: | Doxorubicin induced senescence in a largely p53-dependent manner in HCT116 cells; significantly more senescent cells were observed in HCT116 p53+/+ cells treated with Doxorubicin compared with HCT116 p53?/? cells treated with Doxorubincin . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: