External factors: | Embonic acid |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Other |
Phenotype: | Aging |
Experiment: | SA-β-gal activity assay |
Description: | EA treatment caused a profound increase in the expression of senescence-associated β-galactosidase by H1299 cells. In the absence of EA, the senescent signal,SA-β-gal+ H1299 cells, was not present . |
Target gene: | M-NAD(P)-ME |
R-EF-Target gene: | Downregulation |
Official symbol(s): | M-NAD(P)-ME |
Target gene experiment: | In vitro analysis |
Target gene description: | By in vitro testing of a chemical compound library, we found a natural chemical, EA, which can inhibit m-NAD(P)-ME much more potently than c-NADP-ME. |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: