Aging Overview

External factors

External factors: Embonic acid
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: H1299
PMID: 26008970
Experiment: SA-β-gal activity assay
Description: EA treatment caused a profound increase in the expression of senescence-associated β-galactosidase by H1299 cells. In the absence of EA, the senescent signal,SA-β-gal+ H1299 cells, was not present .


Regulatory relationship

Target gene: M-NAD(P)-ME
R-EF-Target gene: Downregulation
Official symbol(s): M-NAD(P)-ME
Target gene experiment: In vitro analysis
Target gene description: By in vitro testing of a chemical compound library, we found a natural chemical, EA, which can inhibit m-NAD(P)-ME much more potently than c-NADP-ME.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.