| External factors: | DFO |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Cell morphological analysis//Flow cytometry |
| Description: | As expected, progressive enlargement ofcellsizethatisoneofthetypicalsenescentphenotypes was clearly displayed .As expected, the intracellular ROS level increased continuously and the increased ROS was accompanied by the reduced ratio of GSH/GSSG, suggesting that oxidative stress was involved in the DFO-induced senescence. |
| Target gene: | FIS1 |
| R-EF-Target gene: | Downregulation |
| Official symbol(s): | FIS1 |
| Target gene experiment: | Western blot |
| Target gene description: | Under exposure to DFO, expression level of Mfn2 protein increased transiently, but Fis1 protein was progressively decreased . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: