| External factors: | Paclitaxel |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experimental category: | L |
| Tissue type: | Bone marrow |
| Cell name: | MSC1,MSC2,Hs68,Dermal Fibroblast,MRC-5 |
| PMID: | 29321693 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Exposure to 15?nM paclitaxel led to a prolonged accumulation of MSCs in the G2 phase of the cell cycle for up to 96?hours. Both tested MSCs exhibited a swift and significant increase in senescent β-GAL-positive cells ranging between 12 and 20% of cells at 24?hours after treatment and between 20 and 30% after 72?hours. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: