| External factors: | TC-G 1008 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Osteoarthritis |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | SA-β-gal activity assay:The specific GPR39 agonist TC-G 1008 ameliorates IL-1β-induced SA-βgal activity.Flow cytometry:The specific GPR39 agonist TC-G 1008 reduces IL-1b-induced cell cycle arrest in the G1 phase. |
| Target gene: | P53//P21//PAI-1 |
| R-EF-Target gene: | Downregulation//Downregulation//Downregulation |
| Official symbol(s): | P53//P21//SERPINE1 |
| Target gene experiment: | RT-PCR//Western blot |
| Target gene description: | RT-PCR//Western blot:The specific GPR39 agonist TC-G 1008 attenuates the expression of p53, p21, and PAI-1 induced by IL-1b in human primary chondrocytes. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: