| External factors: | Surfactant |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | Various cell types were cultured in the presence of sublethal concentrations of genuine surfactants (NP-40, Triton X-100, SDS, Tween 20, etc) and commercially available products (dishwasher, shampoo, or facial cleansing foam) for 12 weeks. Normal type of cells examined, namely normal human fibroblasts (TIG-7), CK, BK, and FDPC, and all exhibited typical senescence features, flat and enlarged cell shape, and were clearly stained with the senescence-associated β-galactosidase. |
| Regulatory pathway: | p38 |
| R-EF-Pathway: | Activation |
| Official symbol(s): | MAPK14 |
| Pathway experiment: | SA-β-gal activity assay |
| Pathway description: | Among the above inhibitors, only p38 inhibitor SB203580 clearly suppressed the senescence induced by NP-40. It suppressed the senescence induced by oleic acid or SDS as well as NP-40. |
Annotation: