| External factors: | Curcumin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Colorectal cancer |
| Experimental category: | L |
| Tissue type: | -- |
| Cell name: | HROC257 T0 M1,HROC50 T1 M5,HROC60,HROC183 T0 M2 |
| PMID: | 30891459 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | By contrast, all substances and combinations caused senescence in HROC tumor cells with a tendency towards higher β-galactosidase activity after single treatment. Numbers of cells in G0/G1 phase decreased (HROC257 T0 M1 > HROC50 T1 M5 > HROC60 > HROC183 T0 M2; a representative example shows Curcumin/Gemcitabine treated HROC257 T0 M1 (IDOhigh) cells; sub-G1 defines dead cells). The best antiproliferative effect was inducible in HROC183 T0 M2(IDOlow) cells after Indoximod/Curcumin treatment . Percentages of cells in S-phase were 17 % ± 9 % versus 33 % ± 11 % . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: