Aging Overview

External factors

External factors: Arid1B
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Hepatocellular carcinoma
Experimental category: HL
Tissue type: --
Cell name: MEF
PMID: 27737960
Experiment: Knockdown//SA-β-gal activity assay//BrdU assay
Description: Knockdown of Arid1b blunted replicative senescence,as evidenced by increased colony formation, a higher percentage of cells incorpo- rating BrdU, and a decrease in the percentage of senescence-associated β-galactosidase (SA-β-Gal)-positive cells when compared with control MEFs.


Regulatory relationship

Target gene: P16//P21A//P53
R-EF-Target gene: Upregulation//Upregulation//Upregulation
Official symbol(s): P16//P21A//P53
Target gene experiment: DAPI staining//IF
Target gene description: Indeed, the expression of ARID1B not only induced p16INK4a and p21CIP1a but also up-regulated p53 levels and caused DNA damage and oxidative stress .

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.