External factors: | Arid1B |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Chemical compounds |
Phenotype: | Hepatocellular carcinoma |
Experiment: | Knockdown//SA-β-gal activity assay//BrdU assay |
Description: | Knockdown of Arid1b blunted replicative senescence,as evidenced by increased colony formation, a higher percentage of cells incorpo- rating BrdU, and a decrease in the percentage of senescence-associated β-galactosidase (SA-β-Gal)-positive cells when compared with control MEFs. |
Target gene: | P16//P21A//P53 |
R-EF-Target gene: | Upregulation//Upregulation//Upregulation |
Official symbol(s): | P16//P21A//P53 |
Target gene experiment: | DAPI staining//IF |
Target gene description: | Indeed, the expression of ARID1B not only induced p16INK4a and p21CIP1a but also up-regulated p53 levels and caused DNA damage and oxidative stress . |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: