| External factors: | low-Dox |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Cell morphological analysis |
| Description: | At concentrations of 100 ng/ml, doxorubicin (low-Dox) caused senescent morphology, whereas 500 ng/ml of doxorubicin (high-DOX) caused slim cell morphology. |
| Target gene: | P53 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P53 |
| Target gene experiment: | Western blot |
| Target gene description: | At concentrations that caused senescence (100 ng/ml), DOX induced low levels of p53 and did not inhibit S6 phosphorylation, a marker of mTOR activity. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: