| External factors: | H2O2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | H2O2 alone (not in combination with quercetin) promoted the expression of senescence-associated β-galactosidase activity in NIH 3T3 cells. |
| Target gene: | CAVEOLIN-1//P53 |
| R-EF-Target gene: | Activation//Activation |
| Official symbol(s): | CAVEOLIN-1//P53 |
| Target gene experiment: | Luciferase reporter assay |
| Target gene description: | 72 h after induction of oxidative stress with 150 μM H2O2, caveolin-1 promoter activity was increased by ~two fold.3 d after stimulation with H2O2(150 μM for 2 h), the p53 responsive element was activated by ~five- to sixfold. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: