| External factors: | Melatonin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Chronic kidney disease |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Melatonin pretreatment restored cellular morphology of H2o2 -enlarged cells , with 100 μM melatonin most effectively reducing cell size. In addition, 100 μM melatonin -treated CKD -mMSCs showed a substantial reduction in the number of β-gal -positive cells. Furthermore,melatonin significantly downregulated p -P53 and p16INK4A, upregulated SMP30 reduced by H2O2 , and significantly downregulated P21. |
| Target gene: | PRPC |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | PRPC |
| Target gene experiment: | Western blot |
| Target gene description: | CKD -MCSs treated with H2O2 exhibited decreased PrPC , whereas melatonin pretreatment significantly upregulated PrPC. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: