| External factors: | PD0332991 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Glaucoma |
| Experiment: | SA-β-gal activity assay |
| Description: | In addition, PD0332991-treated cells acquired senescent morphology, which became even more prominent when the drug was removed.In RPE cells,PD0332991 (a CDK 4/6 inhibitor) inhibited cell proliferation and resulted in the senescent morphology, typical for these cells.Senescent cells wereunable to proliferate following removal of PD0332991. |
| Target gene: | CYCLIN D1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | CYCLIN D1 |
| Target gene experiment: | Western blot |
| Target gene description: | Most importantly, PD0332991 strongly induced cyclin D1. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: