Aging Overview

External factors

External factors: MLN4924
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Osteosarcoma
Experimental category: HL
Tissue type: --
Cell name: SJSA-1,MG-63
PMID: 27223074
Experiment: SA-β-gal activity assay//Flow cytometry//Cell morphological analysis
Description: We performed a β-galactosidase staining assay and found that most MLN4924-treated OS cells were stained , confirming MLN4924-induced senescence, In flow cytometry cell cycle analysis using propidium iodide DNA staining, a low concentration of MLN4924 (0.04 uM) modestly affected the cell cycle distribution, and a high concentration (1 μM) increased the population of cells in the G2 phase while reducing the S phase population.Furthermore, we observed that a fraction of cells became flat and greatly enlarged after MLN4924 treatment, suggesting an increase in cell senescence.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.