Aging Overview

External factors

External factors: UVB irradiation
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HDF
PMID: 28826096
Experiment: MTT assay//SA-β-gal activity assay
Description: Incremental doses of UVB cause cellular viability decline dose-dependently and at 296 to 696 mJ/cm2doses, the inhibitory effects were significant (P< 0.001);The proportion of positive β-galactosidase cells among UVB-irradiated cells was significantly (P < 0.01) greater than among non-irradiated ones.


Regulatory relationship

Target gene: FOXO3A
R-EF-Target gene: Upregulation
Official symbol(s): FOXO3A
Target gene experiment: qPCR
Target gene description: UVB irradiation significantly upregulated the FOXO3A expression compared to the control cells .

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.