Aging Overview

External factors

External factors: LY2801653
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Cholangiocarcinoma
Experimental category: HL
Tissue type: --
Cell name: TFK-1,SZ-1
PMID: 26757360
Experiment: SA-β-gal activity assay//Western blot
Description: We have analyzed senescence by measuring the senescence associated β-galactosidase (SA-β-Gal) activity assay in TFK-1 and SZ-1 cells after treatment with DMSO and LY2801653. In both cell lines we observed a significant increase in the percentage of SA-β-Gal activity after 48 and 96h compared to their controls.Moreover P21 is one of the major players linking cell cycle arrest and induction of senescence . We observed a strong expression of P21 compared to the untreated controls under 10mM LY2801653 at 96h.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.