| External factors: | Simvastatin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cardiovascular disease |
| Experiment: | SA-β-gal activity assay |
| Description: | As compared to young rats, the percentage of β-galactosidase-positive cells was significantly increased(22.00% + 2.65% vs 83.67% + 9.50%, P < .001). Administra-tion of simvastatin to aged rats significantly lowered the percentage of β-galactosidase-positive cells as compared to that seen in untreated aged rats (68.83% + 7.47% vs 83.67% + 9.50%, P ? .001). |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | Western blot |
| Target gene description: | Pretreatment with simvastatin also significantly inhibited OX-LDL-induced SIRT1 protein downregulation. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: