AgingReG
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Aging Overview

External factors

External factors: A2E
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Age-related macular degeneration
Experimental category: HL
Tissue type: --
Cell name: RPE
PMID: 29415988
Experiment: SA-β-gal activity assay//qRT-PCR
Description: Our results showed that A2E treatment triggered cellular senescence, an effect that was intensified by blue light;We measured telomere length (T/S ratio) using RT-qPCR and found that photosensitization of A2E induced significant telomere erosion, which could be decreased by NAC.

Regulatory relationship

Regulatory pathway: NF-κB
R-EF-Pathway: Activation
Official symbol(s): NFKB1
Pathway experiment: Gene Ontology assay
Pathway description: GO analysis of the upregulated genes also showed a significant enrichment (p <0.05) for 38 GO terms, including“positive regulation of NF-kappa B transcription factor activity”.These findings suggest that the NF-κB pathway is activated upon photosensitization of A2E in RPE cells.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

Activation of NF-kappaB in B cellsAlternative NF-kappaB pathwayamb2 Integrin signalingAngiopoietin receptor Tie2-mediated signalingApoptosis signaling pathwayAtypical NF-kappaB pathwayBCRBCR signaling pathwayCanonical NF-kappaB pathwayCD209 (DC-SIGN) signalingCD40/CD40L signalingCeramide signaling pathwayCLEC7A (Dectin-1) signalingCLEC7A/inflammasome pathwayDEx/H-box helicases activate type I IFN and inflammatory cytokines productionDownstream TCR signalingEGFR1EPO signaling pathwayFc-epsilon receptor I signaling in mast cellsFCERI mediated NF-kB activationGlucocorticoid receptor regulatory networkHIV-1 Nef: Negative effector of Fas and TNF-alphaIkBA variant leads to EDA-IDIKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)IKK-NF-kappaB cascade ( B cell receptor signaling ) IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) IKK-NFkB cascade ( TNFR1 signaling pathway ) IL1-mediated signaling eventsIL1IL12-mediated signaling eventsIL2IL2 signaling events mediated by PI3KIL23-mediated signaling eventsIL3IL4IL5IL6Interleukin-1 processingIntracellular Signalling Through Adenosine Receptor A2a and AdenosineIntracellular Signalling Through Adenosine Receptor A2b and AdenosineLeptinLPA receptor mediated eventsMAP3K8 (TPL2)-dependent MAPK1/3 activationNF-kB is activated and signals survivalNF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) NotchOsteopontin-mediated eventsProlactinRANKLRegulated proteolysis of p75NTRRegulation of TelomeraseRIP-mediated NFkB activation via ZBP1Senescence-Associated Secretory Phenotype (SASP)Signaling events mediated by HDAC Class IT cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) ) T cell receptor signaling pathway ( CD4 T cell receptor signaling ) TAK1 activates NFkB by phosphorylation and activation of IKKs complexTCRTGF_beta_ReceptorTNF receptor signaling pathway TNFalphaTRAF6 mediated NF-kB activationTranscriptional regulation of white adipocyte differentiationTSLPTWEAKMAPK signaling pathwayChemokine signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathwayT cell receptor signaling pathwayB cell receptor signaling pathwayNeurotrophin signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionShigellosisLeishmaniasisChagas diseaseToxoplasmosisAmoebiasisHepatitis CPathways in cancerPancreatic cancerProstate cancerChronic myeloid leukemiaAcute myeloid leukemiaSmall cell lung cancerHs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017Hs_Factors_and_pathways_affecting_insulin-like_growth_factor_(IGF1)-Akt_signaling_WP3850_88165Hs_Leptin_signaling_pathway_WP2034_89856Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910Hs_Apoptosis_Modulation_by_HSP70_WP384_67054Hs_Glucocorticoid_&_Mineralcorticoid_Metabolism_WP237_78497Hs_Allograft_Rejection_WP2328_90020Hs_Oxidative_Damage_WP3941_90810Hs_T-Cell_Receptor_and_Co-stimulatory_Signaling_WP2583_86147Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794Hs_TNF_alpha_Signaling_Pathway_WP231_89895Hs_IL17_signaling_pathway_WP2112_89838Hs_Estrogen_signaling_pathway_WP712_78491Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527Hs_TLR4_Signaling_and_Tolerance_WP3851_90114Hs_IL1_and_megakaryocytes_in_obesity_WP2865_88662Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178Hs_Prolactin_Signaling_Pathway_WP2037_90015Hs_AGE-RAGE_pathway_WP2324_89798Hs_IL-4_Signaling_Pathway_WP395_89828Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937Hs_IL-1_signaling_pathway_WP195_89932Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)