| External factors: | Metformin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | In accordance to these changes, RSV or MET treatment also significantly increased the expression of SMP-30 and decreased the percentage of SA β-Gal staining in HN-treated HUVECs. |
| Regulatory pathway: | SIRT1 |
| R-EF-Pathway: | Upregulation |
| Official symbol(s): | SIRT1 |
| Pathway experiment: | Western blot |
| Pathway description: | When cells were treated with RSV or MET during the incubation in HG for 3 days followed by NG for another 3 days, the expression and deacetylase activity of SIRT1 were significantly increased and the expression of p300, Ac-p53, and p21 was significantly decreased . |
Annotation: