| External factors: | Cisplatin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cancer |
| Experiment: | Cell morphological analysis//SA-β-gal activity assay |
| Description: | 48h after exposure to cisplatin, all of the treated cells became larger and flatter, resembling the morphology of human fibroblasts undergoing senescence. After exposure to low doses of cisplatin, the percentage of SA-β-gal positive cells began to increase at 48 h post-exposure time and reached a peak at 72 h in SUNEl cells and 96 h in HT29 cells. Then the percentage of SA-β-gal positive cells stabilized, correlating to the time when cell growth arrest occurred. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: