| External factors: | EGCG |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal activity significantly(p＜0.05) enhanced in H2O2treated cells with over 60% cells appearing senescent as compared to control group, which was significantly (p＜0.05) abrogated on treatment with EGCG. |
| Regulatory pathway: | PI3K-Akt-mTOR |
| R-EF-Pathway: | Downregulation |
| Official symbol(s): | PI3K-AKT-MTOR |
| Pathway experiment: | Western blot |
| Pathway description: | EGCG treatment significantly (p＜0.05) downregulated expression of both PI3K and Akt as well as p-mTOR(albeit at 100 lM only) suggesting its role in modulation of stress-induced mTOR signaling pathway. A suppression in the gene expression of translation initiation factors (4E-BP1 and eIF4E) downstream of mTOR pathway was also observed that further indicated the inactivation of mTOR pathway in the presence of EGCG. |
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