| External factors: | Ionizing radiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | In order to establish MCF7 cells as a model for irradiationinduced senescence, we investigated further senescence markers,in addition to the enlarged morphology and SA-β-galactosidase activity. |
| Target gene: | IKBζ |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | IKBζ |
| Target gene experiment: | qRT-PCR |
| Target gene description: | In addition to the established SASP factors, also expression of IkBζ, which was almost undetectable in control cells, was increased about 5-fold in senescent MCF7 cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: