| External factors: | EGT |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Photoaging |
| Experiment: | SA-β-gal activity assay |
| Description: | SA-β-gal-positive staining was markedly increased in the vehicle-treated group following irradiation compared to the control group. With higher concentrations of EGT, SA-β-gal staining decreased. |
| Target gene: | HSP70 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | HSP70 |
| Target gene experiment: | Western blot |
| Target gene description: | Following UVB irradiation, the expression of HSP70 was drastically decreased in the vehicle-treated groups compared to the negative control. HSP70 expression was significantly increased in all EGT-treated groups. |
| Regulatory pathway: | Nrf2-HO-1 |
| R-EF-Pathway: | Activation |
| Official symbol(s): | NFE2L2-HMOX1 |
| Pathway experiment: | Western blot |
| Pathway description: | In the vehicle-treated group, expression of Nrf2 was significantly decreased in keratinocytes following UVB irradiation compared to the negative control. However, EGT treatment prevented the decrease in Nrf2 expression following UVB irradiation. HO-1 expression showed a similar pattern in keratinocytes following UVB irradiation. |
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