| External factors: | JQ-101 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Cancer |
| Experiment: | SA-β-gal activity assay//Transwell assay//MTS assay |
| Description: | JQ-101 suppressed LNCaP and H460 tumor cell growth in a dose-dependent manner.Transwell chamber assay system with matrigel coated on the top of an ECM-like membrane to prevent the transmigration of non-invasive cells. Exposure to JQ-101 significantly decreased invasion compared to vehicle control, producing a 3.5-fold reduction in PC3 cell invasion and a 4.2-fold reduction in A549 cells.In contrast,apoptosis was not observed in H1299 cells (data not shown);instead, JQ-101 treatment induced cell senescence in H1299cells. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: