| External factors: | Gemcitabine |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Patients with pancreatic ductal adenocarcinoma |
| Experiment: | SA-β-gal activity assay//qRT-PCR |
| Description: | Gemcitabine efficiently induced senescence in Miapaca-2 and Panc-1 cells in a dose-dependent manner but not in L3.6 pl cells (data not shown), as evidenced by increased SA β-gal staining. Moreover, gemcitabine significantly increased the levels of senescence-associated molecules including P53, P21, P19, PML, and DCR2 in Miapaca-2 and Panc-1 cells, except P53 in Panc1 cells . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: