| External factors: | U0126 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Colorectal cancer |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Cell morphological analysis//Knockdown |
| Description: | Moreover, although all three MAPK inhibitors did not greatly influence cell cycle distribution of unstressed and irradiated cells, p53- and p21-deficient cells rescued by U0126 from γIR-induced apoptosis showed an enlarged and flattened morphology, exhibiting increased senescence-associated β-galactosidase (SA-β-Gal) activities.Remarkably, these senescence markers were even evident when checkpoint-deficient and wild-type HCT116 cells were treated solely with U0126. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: