| External factors: | Ubiquinol-10 |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | -- |
| Description: | For middle (16kHz) and low (8kHz) frequencies, age-associated hearing losses were suppressed by ubiquinol-10 supplementation. |
| Target gene: | SIRT1//PGC-1A//SIRT3 |
| R-EF-Target gene: | Upregulation//Upregulation//Upregulation |
| Official symbol(s): | SIRT1//PGC-1A//SIRT3 |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | We could show that, in agreement with the ABR test and liver results, Sirt3 and Pgc-1a mRNA and protein expression was significantly increased after ubiquinol-10 supplementation. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: