| External factors: | Selaginellin |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Telomerase activity assay//SA-β-gal activity assay//Flow cytometry |
| Description: | Selaginellin concentration dependently inhibited homocysteine-induced cell senescence as shown by the decreased percentages of SA-β-gal–positive cells, the increased telomerase activities, and the decrease in the percentage of cells in the G0/G1phase. |
| Target gene: | SIRT1 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT1 |
| Target gene experiment: | qRT-PCR |
| Target gene description: | In contrast, the decreased mRNA expression of SIRT1 was reversed by pretreatment with selaginellin in a dose-dependent manner. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: