Aging Overview

External factors

External factors: Sulforaphane
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Breast cancer
Experimental category: HL
Tissue type: --
Cell name: MCF-7,SK-BR-3,MDA-MB-231
PMID: 28912888
Experiment: SA-β-gal activity assay//Flow cytometry
Description: An increase of 12.1 and 10.7% in the levels of MCF-7 and MDA-MB-231 cells in the G2/M phase of the cell cycle and an increase of 5.8% in the levels of SK-BR-3 cells in the G0/G1 phase of the cell cycle were observed after 10 μM SFN treatment.After 7 days of SFN removal(5 and 10 μM),an increase in senescence-associated beta-galactosidase (SA-β-gal)-positive cells was observed in three breast cancer cells considered .


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.