| External factors: | H2O2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | The cells treated with H2O2 at 62.5?μM cells were stained with darker blue color than young cells. In addition, the size of cells got larger with the dose of H2O2 similar to the phenotype of old cells. |
| Target gene: | MITF//NRF2 |
| R-EF-Target gene: | Downregulation//Upregulation |
| Official symbol(s): | MITF//NRF2 |
| Target gene experiment: | Western blot |
| Target gene description: | The expression level of MITF in senescent cells and H2O2-treated cells decreased by 16% and 39% compared to that of young cells, respectively;The expression levels of Nrf2 were increased 15% and 5% in senescent cells and H2O2-treated cells compared with young cells, respectively. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: