Aging Overview

External factors

External factors: Zn
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: HCAEC
PMID: 28918363
Experiment: SA-β-gal activity assay//Flow cytometry//qRT-PCR//Western blot
Description: Almost all Zn-treated cells (approximately 90%) had undergone cell death by passage 11, whereas only approximately 40% of control cells had undergone cell death by this point. Measurement of SA-β-gal staining and p16 expression as biomarkers of senescence revealed increases induced by the Zn treatment at late passages.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.