| External factors: | Doxorubicin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Cell proliferation assay//MTT assay//qRT-PCR |
| Description: | When MSCs were treated with DOXO at a concentration of 5 mol/l, the proliferation rate decreased significantly, starting immediately after treatment and lasting for 7 days . Furthermore, DOXO treatment significantly decreased MSC viability compared with the control group, as measured by the MTT assay.Furthermore, the expression of the senescence-associated genes cellular tumor antigen p53 and p16 was significantly increased in the DOXO treatment group compared with the control group . |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: