| External factors: | Costunolide |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Glioblastoma |
| Experiment: | SA-β-gal activity assay |
| Description: | Costunolide-induced increase in β-gal-positive cells, indicative of senescence, was diminished in the presence of ROS inhibitor. |
| Target gene: | GS(P)//TKT |
| R-EF-Target gene: | Downregulation//Downregulation |
| Official symbol(s): | APC//TKT |
| Target gene experiment: | Western blot |
| Target gene description: | Costunolide-mediated decrease in tumor volume was accompanied by decreased expression of TERT, Nrf2, G6PD, TKT, and GS(P) levels . Costunolide-induced senescence was accompanied by decreased expression of GS(P) and increased glycogen accumulation in an ROS-dependent manner. The extent of glycogen accumulation was cell line dependent. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: