AgingReG
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Aging Overview

External factors

External factors: Melatonin
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: Aorta
Cell name: --
PMID: 22109832
Experiment: Histological staining
Description: In control mice not treated and treated with FAST or RETARD melatonin and in APOE-treated mice with both formulations of melatonin,the vessels showed a normal morphology.

Regulatory relationship

Regulatory pathway: SIRT1-p53-eNOS
R-EF-Pathway: --
Official symbol(s): SIRT1-TP53-NOS3
Pathway experiment: Immunostaining
Pathway description: SIRT1 was expressed in cytoplasm and nuclei of tunica intima cells of APOE FAST-and RETARD-treated mice.On the contrary, intima, media, and adventitial cells were negative in the vessels of control mice and in those given either APOE FAST or RETARD melatonin .Melatonin treatments restored significantly the expression of this protein after either in APOE FAST or RETARD melatonin treatment. This positivity was moderate in ECs of APOE FAST-treated animals and strong in APOE RETARD-treated mice.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AndrogenReceptorCircadian ClockE2F transcription factor networkFoxO family signalingHIF-2-alpha transcription factor networkp53 pathwayp73 transcription factor networkRegulation of Androgen receptor activityRegulation of HSF1-mediated heat shock responseRegulation of retinoblastoma proteinRORA activates gene expressionSignaling events mediated by HDAC Class ISignaling events mediated by HDAC Class IIISIRT1 negatively regulates rRNA ExpressionHs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Simplified_Interaction_Map_Between_LOXL4_and_Oxidative_Stress_Pathway_WP3670_90107Hs_Energy_Metabolism_WP1541_91584Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178Hs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947
Activation of PUMA and translocation to mitochondriaAP-1 transcription factor networkApoptosis signaling pathwayAssociation of TriC/CCT with target proteins during biosynthesisAurora A signalingAutodegradation of the E3 ubiquitin ligase COP1BARD1 signaling eventsDirect p53 effectorsDNA Damage/Telomere Stress Induced SenescenceEGFR1Factors involved in megakaryocyte development and platelet productionFormation of Senescence-Associated Heterochromatin Foci (SAHF)G2/M CheckpointsG2/M DNA damage checkpointGlucocorticoid receptor regulatory networkHuntington diseaseHypoxic and oxygen homeostasis regulation of HIF-1-alphaLKB1 signaling eventsOncogene Induced SenescenceOxidative Stress Induced Senescencep53 pathway by glucose deprivationp53 pathwayp53 pathwayP53 pathway feedback loops 1p53 pathway feedback loops 2p75(NTR)-mediated signalingPLK3 signaling eventsPre-NOTCH Transcription and TranslationRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksRegulation of TP53 Activity through AcetylationRegulation of TP53 Activity through Association with Co-factorsRegulation of TP53 Activity through MethylationRegulation of TP53 Activity through PhosphorylationRegulation of TP53 DegradationSignaling events mediated by HDAC Class IIISignaling mediated by p38-alpha and p38-betaStabilization of p53SUMOylation of transcription factorsTGF_beta_ReceptorThe role of GTSE1 in G2/M progression after G2 checkpointTNFalphaTP53 Regulates Metabolic GenesTP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTP53 Regulates Transcription of Caspase Activators and CaspasesTP53 Regulates Transcription of Death Receptors and LigandsTP53 Regulates Transcription of DNA Repair GenesTP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainValidated targets of C-MYC transcriptional activationVinblastine Action PathwayVincristine Action PathwayVindesine Action PathwayVinorelbine Action PathwayMAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)Huntington's diseaseHepatitis CPathways in cancerColorectal cancerPancreatic cancerEndometrial cancerGliomaProstate cancerThyroid cancerBasal cell carcinomaMelanomaBladder cancerChronic myeloid leukemiaSmall cell lung cancerNon-small cell lung cancerHs_Cell_Cycle_WP179_89516Hs_Tryptophan_metabolism_WP465_85055Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_TP53_Network_WP1742_71700Hs_DNA_Damage_Response_WP707_82937Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694Hs_Nuclear_Receptors_in_Lipid_Metabolism_and_Toxicity_WP299_89331Hs_Gastric_Cancer_Network_2_WP2363_87523Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293Hs_Alzheimers_Disease_WP2059_87372Hs_Copper_homeostasis_WP3286_89205Hs_Integrated_Cancer_Pathway_WP1971_82939Hs_ATM_Signaling_Pathway_WP2516_90247Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271Hs_LncRNA-mediated_mechanisms_of_therapeutic_resistance_WP3672_87395Hs_Bladder_Cancer_WP2828_89143Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520Hs_Steroid_Biosynthesis_WP496_69016Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639Hs_G1_to_S_cell_cycle_control_WP45_80001
AngiogenesisAngiopoietin receptor Tie2-mediated signalingArginine and Proline metabolism ( Arginine and Proline metabolism ) citrulline-nitric oxide cycleDoxorubicin Metabolism PathwayEGFR1eNOS activationInterleukin signaling pathwayLeptinNitric oxide stimulates guanylate cyclaseNOSTRIN mediated eNOS traffickingPAR1-mediated thrombin signaling eventsPI3 kinase pathwayPlasma membrane estrogen receptor signalingROS, RNS production in response to bacteriaSHP2 signalingSignaling events mediated by VEGFR1 and VEGFR2Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationThromboxane A2 receptor signalingValidated transcriptional targets of AP1 family members Fra1 and Fra2VEGF signaling pathwayVEGFR1 specific signalsVEGFR2 mediated vascular permeabilityuntitledArginine and proline metabolismCalcium signaling pathwayHs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017Hs_PI3K-AKT-mTOR_signaling_pathway_and_therapeutic_opportunities_WP3844_89952Hs_Angiogenesis_WP1539_88983Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)