| External factors: | Trans-Cinnamaldehyde |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Immunostaining//SA-β-gal activity assay//ELISA |
| Description: | We found that the number of Ki-67 positive cells was dramatically decreased after H2O2 induction,however, the number of Ki-67 positive cells was greatly enhanced by subsequent TC treatment;The percentage of SA-β-gal positive cells was decreased dramatically when H2O2-induced cells were treated with TC, confirming its anti-senescent effects ;The TC-treated ADSCs post H2O2 treatment showed increased telomerase activity when compared to the H2O2 group. |
| Target gene: | SIRT1//P53//P21 |
| R-EF-Target gene: | Upregulation//Downregulation//Downregulation |
| Official symbol(s): | SIRT1//P53//P21 |
| Target gene experiment: | Semi-qPCR//qPCR |
| Target gene description: | Upregulation of SIRT1 in TC-treated ADSCs post H2O2 treatment is a vital indicator of antisenescence capacity of TC ;When rescued by TC treatment, the expression of p21 and p53 seemed to reduce. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: