External factors: | Norcantharidin |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Chemical compounds |
Phenotype: | Lung cancer |
Experiment: | SA-β-gal activity assay |
Description: | SA-β-Gal assay showing that NCTD at 15 μM significantly increased cell senescence phenotype in A549 cells for 72 h. |
Regulatory pathway: | YAP |
R-EF-Pathway: | Downregulation |
Official symbol(s): | YAP1 |
Pathway experiment: | RT-PCR//Western blot |
Pathway description: | NCTD time-dependently reduced Yap mRNA(E) and protein level (F) in A549 cells at 15 μΜ. |
Annotation: