Aging Overview

External factors

External factors: Norcantharidin
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Lung cancer
Experimental category: L
Tissue type: Lung
Cell name: A549
PMID: 27903989
Experiment: SA-β-gal activity assay
Description: SA-β-Gal assay showing that NCTD at 15 μM significantly increased cell senescence phenotype in A549 cells for 72 h.


Regulatory relationship

Regulatory pathway: YAP
R-EF-Pathway: Downregulation
Official symbol(s): YAP1
Pathway experiment: RT-PCR//Western blot
Pathway description: NCTD time-dependently reduced Yap mRNA(E) and protein level (F) in A549 cells at 15 μΜ.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view