Aging Overview

External factors

External factors: Ang II
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: Glomerular mesangial cell
PMID: 30389500
Experiment: Western blot//SA-β-gal activity assay
Description: Compared with the normal control group, the western blotting analysis showed that the expression levels of the senescence-related proteins p53 and p21 rose gradually as the duration of the 10-6 mmol/L Ang II treatment increased. The rate of positive β-galactosidase staining reached 65.43±1.31% after treatment of Ang II for 72 h, which was significantly higher than the rate obtained in the normal control group.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.