| External factors: | Ethanol |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Atherosclerosis |
| Experiment: | SA-β-gal activity assay |
| Description: | Ethanol could decrease SA-β-gal positive cells in the plaque surface. Furthermore, to explore the effects of ethanol on endothelial cells, the ratio of Ac-p53/p16-to CD31-stained areas was assessed. The area ratios of Ac-p53/CD31 and p16/CD31 were significantly attenuated by ethanol, suggesting the inhibitory effects of ethanol on endothelial senescence. |
| Target gene: | ALDH2 |
| R-EF-Target gene: | Activation |
| Official symbol(s): | ALDH2 |
| Target gene experiment: | Western blot |
| Target gene description: | In addition, the 0.3 g/kg dose of ethanol increased the protein expression and activity of ALDH2, while the lower and higher doses had little effect .The 0.3 g/kg dose of ethanol also increased the ALDH2-positive staining area. These results indicate that the appropriate dose of ethanol promotes ALDH2 activation in the artery vessel wall. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: