Aging Overview

External factors

External factors: Crataegus extract
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: Endothelial cell
PMID: 26672612
Experiment: SA-β-gal activity assay
Description: The Crataegus extract concentration-dependently reduced the increased SA-β-gal activity in cells at P2, P3, and P4.


Regulatory relationship

Regulatory pathway: eNOS
R-EF-Pathway: --
Official symbol(s): NOS3
Pathway experiment: Flow cytometry//SA-β-gal activity assay
Pathway description: The protective effect of the Crataegus treatment in cells at P3 was not observed in the presence of L-NAME indicating the key role of eNOS-derived NO.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view