Aging Overview

External factors

External factors: R1530
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Cancer
Experimental category: L
Tissue type: --
Cell name: H460,HCT116
PMID: 20814247
Experiment: SA-β-gal activity assay//BrdU Assay
Description: Not all polyploid cells underwent apoptosis in the presence of R1530. A substantial fraction remained viable but stopped replication and acquired a senescence phenotype.The representative cell in the time-lapse sequence ceased to proliferate after one cycle of abortive mitosis/endo-reduplication but continued to grow and nearly tripled its initial size. These morphological changes correlated very well with the decrease in the BrdU labeling index and the kinetics of staining for senescence-associated β-galactosidase activity (SA-β-Gal), the most widely recognized senescence marker11.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.